Hereditary Bisalbuminemia in Sjögren’s Syndrome and Rheumatoid Arthritis

Bisalbuminemia is rare finding of bifid albumin bands in serum electrophoresis. The protein abnormality can be sporadic and inherited. So far, this albumin variant was not found to cause or coexist with a specific pathology. This is a case of bisalbuminemia in 43-year-old female patient with a past medical history of Rheumatoid Arthritis (RA) and Sjogren’s Syndrome (SS). Similar electrophoresis findings were seen in two siblings of the patient. Rheumatology focused work-up of the family was negative. We could not find an association between this blood protein variant and the patient’s rheumatologic condition. Bisalbuminemia should not be a concern to the rheumatologist as it does not hint towards pathology.