Oat nutritious meal has beneficial effect on lipid metabolism in type 2 diabetes mellitus: A 3-month randomized controlled trial

[Display omitted] •ONM has beneficial effects on lipid metabolism in elderly patients with T2DM.•ONM intervention led to the reduction in TC and LDL-c levels compared to the control group during the follow-up.•ONM has beneficial effect on cholesterol control, it could be a good food choice on lipid control for T2DM patients. This study aims to evaluate the effects of oat nutritious meal (ONM) on the blood glucose and lipid metabolism in elderly patients with type 2 diabetes mellitus (T2DM). A randomized controlled trial (RCT) was conducted. Ninety-eight subjects were randomlydivided into ONM group and control group. The ONM group was given 20 g ONM twice a day over a course of 3 months and the control group kept the diet as before. Glucose and lipids parameters were measured at baseline and once a month in the study. Repeated-measure analysis of variance was used for data analysis. We found that there were significant changes in the concentrations of fasting plasma glucose, 2-hour postprandial plasma glucose, 2-hour postprandial insulin, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c) and homeostasis model assessment for beta-cell function(HOMA-β) over time in both groups. For TC and LDL-c, the interaction between time and intervention was also significant, which indicated that the ONM intervention contributed to the reduction of TC and LDL-c levels compared to the control group during the follow-up (P = 0.026 for TC, P = 0.006 for LDL-c). Our research demonstrates that 40 g ONM/d reduces TC and LDL-c levels significantly. But it has no effect on the glucose metabolism in elderly patients with T2DM.