Primary neuroendocrine carcinoma of brain radiologically mimicking high grade glioma: A case report and review of literature

Abstract Primary neuro-endocrine carcinoma (NEC) of central nervous system is extremely rare; only one case is reported till date. It mainly involves the dura, frontal lobe and paranasal sinus close to anterior skull base. We report a case of intrinsic brain tumor in left frontal lobe with extension to corpus callosum whose pre-operative MRI diagnosis was high grade glioma. He was operated, intra operative squash and post operative histopathological diagnosis of the tumor came as high grade glioma. However, on immunohistochemical (IHC) study the diagnosis turned out to be primary neuro endocrine carcinoma of brain.