Disturbed oscillatory brain dynamics in subcortical ischemic vascular dementia

White matter hyperintensities (WMH) can lead to dementia but the underlying physiological mechanisms are unclear. We compared relative oscillatory power from electroencephalographic studies (EEGs) of 17 patients with subcortical ischemic vascular dementia, based on extensive white matter hyperintens...

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Veröffentlicht in:	BMC neuroscience 2012-07, Vol.13 (1), p.85-85, Article 85
Hauptverfasser:	van Straaten, Elisabeth C W, de Haan, Willem, de Waal, Hanneke, Scheltens, Philip, van der Flier, Wiesje M, Barkhof, Frederik, Koene, Ted, Stam, Cornelis J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer's disease Analysis of Variance Binswanger's disease Biological Clocks - physiology Brain Brain - physiopathology Brain Mapping Brain Waves - physiology Cognition Cognition Disorders - diagnosis Cognition Disorders - etiology Cognitive ability Dementia Dementia disorders Dementia, Vascular - complications Dementia, Vascular - pathology Dementia, Vascular - physiopathology Diagnosis EEG Electroencephalography Female Humans Ischemia Male Medical imaging Medical research Medicine, Experimental Nervous system Neurons Neuropsychological Tests Oscillations Physiological aspects Regression analysis Relative power Spectral analysis Spectrum Analysis Substantia alba Vascular dementia White matter
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Zusammenfassung:	White matter hyperintensities (WMH) can lead to dementia but the underlying physiological mechanisms are unclear. We compared relative oscillatory power from electroencephalographic studies (EEGs) of 17 patients with subcortical ischemic vascular dementia, based on extensive white matter hyperintensities (SIVD-WMH) with 17 controls to investigate physiological changes underlying this diagnosis. Differences between the groups were large, with a decrease of relative power of fast activity in patients (alpha power 0.25 ± 0.12 versus 0.38 ± 0.13, p = 0.01; beta power 0.08 ± 0.04 versus 0.19 ± 0.07; p
ISSN:	1471-2202 1471-2202
DOI:	10.1186/1471-2202-13-85