Combination therapy of trichloroacetic acid, human autologous fibroblast injection and fibroblast seeded microfibrous collagen scaffold as a novel treatment for osteomyelitis diabetic foot ulcer

A severe complication associated with diabetes is diabetic foot ulcer (DFU). Most patients with DFU require amputation. Although treatment of non‐healing diabetic ulcers is challenging, the use of novel therapies can be effective. In this report, we present the case of a woman with type 2 diabetes with DFU‐related osteomyelitis, who was treated with a combination therapy of trichloroacetic acid, calcium alginate and foam dressings, human autologous fibroblast injection, and a fibroblast cell‐seeded collagen scaffold. The results showed the positive effects of combination therapy on DFU. In the initial treatment, the wound area was measured to be 14 × 7 cm2, with a depth of 4 cm. After 6 months, the wound was measured to be 1.5 cm2, showing a 90% reduction of the wound area. Overall, this combination therapy was highly effective in the treatment of DFU‐related osteomyelitis, and could markedly prevent amputation among DFU patients. Combination therapy using trichloroacetic acid, calcium alginate and foam dressing, human autologous fibroblast injection, and fibroblast cells seeded collagen scaffold is very effective for the treatment of a diabetic foot ulcer with osteomyelitis, and can markedly prevent amputation among diabetic foot ulcer patients.