Synthesis of the aglycon of scorzodihydrostilbenes B and D

Synthesis of the aglycon of scorzodihydrostilbenes B and D

Benzyl- and methyl-protected 2,4-dihydroxyacetophenones are added under ruthenium catalysis to 4-methoxy- and 3,4-dimethoxystyrene in a completely regioselective manner. Thus, oxygenated dihydrostilbenes are obtained that feature the skeleton of scorzodihydrostilbenes - antioxidative agents that wer...

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Veröffentlicht in:Beilstein journal of organic chemistry 2019-03, Vol.15 (1), p.610-616
Hauptverfasser: Weimann, Katja, Braun, Manfred
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
C–H activation
Full Research Paper
hydroarylation
phenols
regioselectivity
ruthenium
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Zusammenfassung:Benzyl- and methyl-protected 2,4-dihydroxyacetophenones are added under ruthenium catalysis to 4-methoxy- and 3,4-dimethoxystyrene in a completely regioselective manner. Thus, oxygenated dihydrostilbenes are obtained that feature the skeleton of scorzodihydrostilbenes - antioxidative agents that were recently isolated from . Selective deprotection liberates the corresponding phenols, among them the aglycon of scorzodihydrostilbenes B and D.
ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.15.56