ε2 allele and ε2-involved genotypes (ε2/ε2, ε2/ε3, and ε2/ε4) may confer the association of APOE genetic polymorphism with risks of nephropathy in type 2 diabetes: a meta-analysis

Diabetic nephropathy (DN) contributes to end-stage renal failure. Microvascular injury resulted from reactive oxygen species is implicated in the pathogenesis of DN. Genetic polymorphism of Apolipoprotein E (APOE) influences the antioxidative properties of the protein. The relationship of APOE polym...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Lipids in health and disease 2020-06, Vol.19 (1), p.136-136, Article 136
Hauptverfasser:	Shi, Jikang, Cheng, Zhaorui, Qiu, Shuang, Cui, Heran, Gu, Yulu, Zhao, Qian, Ren, Yaxuan, Zhang, He, Sun, Helin, Liu, Yunkai, Li, Yong, Qiao, Yichun, Hu, Yueyang, Liu, Yawen, Cheng, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Apolipoprotein E Apolipoprotein E2 - genetics Apolipoproteins Apolipoproteins E - genetics Association Bias Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - pathology Diabetic Nephropathies - etiology Diabetic Nephropathies - genetics Diabetic Nephropathies - pathology Diabetic nephropathy End-stage renal disease Female Gene polymorphism Genetic Association Studies Genetic Predisposition to Disease Genotype Genotype & phenotype Humans Kidney diseases Male Meta-analysis Microvasculature Nephropathy Oxidative stress Polymorphism Polymorphism, Single Nucleotide - genetics Population Quality Reactive oxygen species Renal failure Risk Risk Factors Sensitivity analysis Statistical analysis Type 2 diabetes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Diabetic nephropathy (DN) contributes to end-stage renal failure. Microvascular injury resulted from reactive oxygen species is implicated in the pathogenesis of DN. Genetic polymorphism of Apolipoprotein E (APOE) influences the antioxidative properties of the protein. The relationship of APOE polymorphism with the risks of nephropathy in type 2 diabetes (T2DN) remains elusive. An up-to-date meta-analysis was conducted on the basis of studies selected from PubMed, WanFang database, Embase, Vip database, Web of Science, Scopus, and CNKI database. A total of 33 studies conferring 3266 cases and 3259 controls were selected on the basis of criteria of inclusion and exclusion in this meta-analysis. For APOE alleles, the pooled odds ratio (OR) of ε2 vs. ε3 was 1.89 (95% confidence intervals [95% CI]: 1.49-2.38, P
ISSN:	1476-511X 1476-511X
DOI:	10.1186/s12944-020-01307-6