Single and repeated dose (28 days) intravenous toxicity assessment of bartogenic acid (an active pentacyclic triterpenoid) isolated from Barringtonia racemosa (L.) fruits in mice

Single and repeated dose (28 days) intravenous toxicity assessment of bartogenic acid (an active pentacyclic triterpenoid) isolated from Barringtonia racemosa (L.) fruits in mice

[Display omitted] •BA has structural similarity with oleanolic acid (OA) & ursolic acid (UA).•OA and UA are currently being evaluated in clinical trial under cancer therapy.•BA has been reported for chemomodulatory, anti-cancer & anti-tumor activities.•Toxicity profiling of Bartogenic acid (...

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Veröffentlicht in:Current research in toxicology 2022-01, Vol.3, p.100057-100057, Article 100057
Hauptverfasser: Dubey, Vishal Kumar, Madan, Swati, Rajput, Satyendra K., Singh, Anu T, Jaggi, Manu, Mittal, Amit Kumar
Format: Artikel
Sprache:eng
Schlagworte:
Acute
Barringtonia racemosa
Bartogenic acid
Mice
NOAEL
Toxicity
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Zusammenfassung:[Display omitted] •BA has structural similarity with oleanolic acid (OA) & ursolic acid (UA).•OA and UA are currently being evaluated in clinical trial under cancer therapy.•BA has been reported for chemomodulatory, anti-cancer & anti-tumor activities.•Toxicity profiling of Bartogenic acid (BA) yet to prove in the scientific literature.•Single dose of BA treatment (100 mg/kg) showed mortality.•NOAEL for BA were found to be
ISSN:2666-027X
2666-027X
DOI:10.1016/j.crtox.2021.10.004