Molecular epidemiology and antimicrobial resistance phenotype of paediatric bloodstream infections caused by Gram-negative bacteria

Molecular epidemiology and antimicrobial resistance phenotype of paediatric bloodstream infections caused by Gram-negative bacteria

Background Gram-negative organisms are common causes of bloodstream infection (BSI) during the neonatal period and early childhood. Whilst several large studies have characterised these isolates in adults, equivalent data (particularly incorporating whole genome sequencing) is lacking in the paediat...

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Veröffentlicht in:Communications medicine 2022-08, Vol.2 (1), p.101-8, Article 101
Hauptverfasser: Lipworth, Sam, Vihta, Karina-Doris, Davies, Tim, Wright, Sarah, Tabirao, Merline, Chau, Kevin, Vaughan, Alison, Kavanagh, James, Barker, Leanne, George, Sophie, Segal, Shelley, Paulus, Stephane, Barrett, Lucinda, Oakley, Sarah, Jeffery, Katie, Butcher, Lisa, Peto, Tim, Crook, Derrick, Walker, Sarah, Kadambari, Seilesh, Stoesser, Nicole
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Sprache:eng
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Zusammenfassung:Background Gram-negative organisms are common causes of bloodstream infection (BSI) during the neonatal period and early childhood. Whilst several large studies have characterised these isolates in adults, equivalent data (particularly incorporating whole genome sequencing) is lacking in the paediatric population. Methods We perform an epidemiological and sequencing based analysis of Gram-negative bloodstream infections (327 isolates (296 successfully sequenced) from 287 patients) in children
ISSN:2730-664X
2730-664X
DOI:10.1038/s43856-022-00161-0