Long-term cost-effectiveness of the fixed-dose combination of tiotropium plus olodaterol based on the DYNAGITO trial results

Combinations of long-acting bronchodilators are recommended to reduce the rate of COPD exacerbations. Evidence from the DYNAGITO trial showed that the fixed-dose combination of tiotropium + olodaterol reduced the annual rate of total exacerbations (

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Bibliographische Detailangaben
Veröffentlicht in:	International journal of chronic obstructive pulmonary disease 2019-01, Vol.14, p.447-456
Hauptverfasser:	Hoogendoorn, Martine, Corro Ramos, Isaac, Baldwin, Michael, Luciani, Laura, Fabron, Cecile, Detournay, Bruno, Rutten-van Mölken, Maureen P M H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Benzoxazines - adverse effects Benzoxazines - economics Benzoxazines - therapeutic use Bronchodilator Agents - adverse effects Bronchodilator Agents - economics Bronchodilator Agents - therapeutic use Chronic obstructive pulmonary disease Comparative analysis Computer Simulation COPD Cost analysis Cost Savings Cost-Benefit Analysis costs Disease Progression Dosage and administration Drug Combinations Drug Costs Drug prices Drug therapy, Combination Economic aspects exacerbations Exercise Female Forced Expiratory Volume France Health care expenditures Humans Lung - drug effects Lung - physiopathology Male Middle Aged modeling Models, Economic olodaterol Original Research Patients Pharmaceutical industry Physical fitness Pneumonia Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - economics Pulmonary Disease, Chronic Obstructive - physiopathology QALYs Quality of Life Quality-Adjusted Life Years Randomized Controlled Trials as Topic Reimbursement Sensitivity analysis Simulation Steroids Time Factors Tiotropium Tiotropium Bromide - adverse effects Tiotropium Bromide - economics Tiotropium Bromide - therapeutic use Treatment Outcome
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Beschreibung
Zusammenfassung:	Combinations of long-acting bronchodilators are recommended to reduce the rate of COPD exacerbations. Evidence from the DYNAGITO trial showed that the fixed-dose combination of tiotropium + olodaterol reduced the annual rate of total exacerbations (
ISSN:	1178-2005 1176-9106 1178-2005
DOI:	10.2147/COPD.S191031