The Role of MIF in Type 1 and Type 2 Diabetes Mellitus

Autoimmunity and chronic low-grade inflammation are hallmarks of diabetes mellitus type one (T1DM) and type two (T2DM), respectively. Both processes are orchestrated by inflammatory cytokines, including the macrophage migration inhibitory factor (MIF). To date, MIF has been implicated in both types...

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Veröffentlicht in:	Journal of Diabetes Research 2014-01, Vol.2014 (2014), p.1-6
Hauptverfasser:	Sánchez-Zamora, Yuriko I., Rodríguez-Sosa, Miriam
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Arthritis Cardiovascular disease Chronic illnesses Cytokines Diabetes Diabetes Mellitus, Type 1 - etiology Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - physiopathology Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - immunology Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Diabetic retinopathy Disease Progression Health aspects Humans Hypotheses Inflammation Inflammatory bowel disease Insulin - metabolism Insulin resistance Insulin Secretion Insulin-Secreting Cells - immunology Insulin-Secreting Cells - metabolism Intramolecular Oxidoreductases - metabolism Macrophage Migration-Inhibitory Factors - metabolism Metabolism Models, Biological Obesity Physiological aspects Plasma Proteins Review Transplants & implants Tumor necrosis factor-TNF Type 1 diabetes Type 2 diabetes
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Beschreibung
Zusammenfassung:	Autoimmunity and chronic low-grade inflammation are hallmarks of diabetes mellitus type one (T1DM) and type two (T2DM), respectively. Both processes are orchestrated by inflammatory cytokines, including the macrophage migration inhibitory factor (MIF). To date, MIF has been implicated in both types of diabetes; therefore, understanding the role of MIF could affect our understanding of the autoimmune or inflammatory responses that influence diabetic pathology. This review highlights our current knowledge about the involvement of MIF in both types of diabetes in the clinical environment and in experimental disease models.
ISSN:	2314-6745 2314-6753
DOI:	10.1155/2014/804519