lncRNA IGF2‐AS regulates miR‐500a‐3p/PPP4R1/p‐VEGFR2 signalling pathway to promote thyroid carcinoma progression and tubulogenesis

To the Editor Thyroid carcinoma (THCA) continues to rise globally, with an estimated 52 890 new cases and 2180 deaths in the United States in 2020.1 It is reported that an increasing number of long noncoding RNAs (lncRNAs) have been involved in cancer development.2–4 The importance of lncRNAs in cancer, including epigenetic control, DNA damage, cell cycle regulation, regulation of microRNAs, engagement in signal transduction pathways and mediation of hormone-induced cancer, is not to be ignored. Tumours collected from mice were exhibited and measured (Figure S8A–C). [...]the PPP4R1 mRNA expression of the sh-PPP4R1 group was significantly decreased in tumours compared with sh-NC treatment group (Figure S8D). ACKNOWLEDGEMENTS This work was financially supported by the National Natural Science Foundation of China (Nos. 31501149, 31770815 and 31570764), Hubei Natural Science Foundation (2021CFB230 and 2022CFB026), Wuhan Health and Family Planning Scientific Research Project (WX21Q49), Educational Commission of Hubei (B2020001), Hubei Province Health and Family Planning Scientific Research Project (WJ2021Q051 and WJ2019M255), Hubei Province Key R&D Program (No. 2022BCA007), Frontier Project of Applied Basic Research in Wuhan (2020020601012250) and “The 14th Five Year Plan” Hubei Provincial advantaged characteristic disciplines (gropus) project of Wuhan University of Science and Technology (2023C0303). CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest.