The Display between HPV Infection and Host Immunity in Cervical Cancer

Most cervical cancers are related to the persistent infections of high-risk Human Papillomavirus (HPV) infections. Increasing evidence has witnessed the immunosuppressive effectiveness of HPV in the oncogenesis steps and progression steps. Here we review the immune response in HPV-related cervical m...

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Veröffentlicht in:	Frontiers in bioscience (Landmark. Print) 2024-12, Vol.29 (12), p.426
Hauptverfasser:	Gu, Yuanyuan, Li, Tingting, Zhang, Menglei, Chen, Junhao, Shen, Fang, Ding, Jingxin, Zhou, Guannan, Hua, Keqin
Format:	Artikel
Sprache:	eng
Schlagworte:	cervical cancer Female Host-Pathogen Interactions - immunology human papillomavirus (hpvs) Humans immune response immunotherapies Immunotherapy - methods landscape Papillomaviridae - immunology Papillomavirus Infections - immunology Papillomavirus Infections - virology Uterine Cervical Neoplasms - immunology Uterine Cervical Neoplasms - virology
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Beschreibung
Zusammenfassung:	Most cervical cancers are related to the persistent infections of high-risk Human Papillomavirus (HPV) infections. Increasing evidence has witnessed the immunosuppressive effectiveness of HPV in the oncogenesis steps and progression steps. Here we review the immune response in HPV-related cervical malignancies and discuss the crosstalk between HPVs and the host immune response. Furthermore, we describe the identification and development of current immunotherapies in cervical cancer. Above all, we hope to provide a novel insight of the display between HPV infections and the host immune system.
ISSN:	2768-6701 2768-6698 2768-6698
DOI:	10.31083/j.fbl2912426