Glycobiology of Cancer: Sugar Drives the Show

Glycobiology of Cancer: Sugar Drives the Show

Cancer development and progression is associated with aberrant changes in cellular glycosylation. Cells expressing altered glycan-structures are recognized by cells of the immune system, favoring the induction of inhibitory immune processes which subsequently promote tumor growth and spreading. Here...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Medicines (Basel, Switzerland) Switzerland), 2022-05, Vol.9 (6), p.34
Hauptverfasser: dos Reis, Jhenifer Santos, Rodrigues da Costa Santos, Marcos André, Mendonça, Daniella Pereira, Martins do Nascimento, Stefani Ingrid, Barcelos, Pedro Marçal, Correia de Lima, Rafaela Gomes, da Costa, Kelli Monteiro, Freire-de-Lima, Celio Geraldo, Morrot, Alexandre, Previato, Jose Osvaldo, Mendonça Previato, Lucia, da Fonseca, Leonardo Marques, Freire-de-Lima, Leonardo
Format: Artikel
Sprache:eng
Schlagworte:
Antigens
Cancer
Disease
Drug resistance
Genotype & phenotype
glycome
glycomedicine
glycosylation
glycosyltransferases
Immunotherapy
Metastasis
Molecular biology
Opinion
Proteins
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Cancer development and progression is associated with aberrant changes in cellular glycosylation. Cells expressing altered glycan-structures are recognized by cells of the immune system, favoring the induction of inhibitory immune processes which subsequently promote tumor growth and spreading. Here, we discuss about the importance of glycobiology in modern medicine, taking into account the impact of altered glycan structures expressed in cancer cells as potential glycobiomarkers of disease, as well as on cancer development and progression.
ISSN:2305-6320
2305-6320
DOI:10.3390/medicines9060034