Meaningful cognitive decline is uncommon in virally suppressed HIV, but sustained impairment, subtle decline and abnormal cognitive aging are notResearch in context

Meaningful cognitive decline is uncommon in virally suppressed HIV, but sustained impairment, subtle decline and abnormal cognitive aging are notResearch in context

Background: High antiretroviral therapy (ART) coverage and viral suppression among people with HIV (PWH) in Australia provide a unique context to study individual cognitive trajectories, cognitive aging and factors associated with longitudinal cognitive function during chronic and stable HIV disease...

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Veröffentlicht in:EClinicalMedicine 2023-02, Vol.56, p.101792
Hauptverfasser: Htein Linn Aung, Krista J. Siefried, Thomas M. Gates, Bruce J. Brew, Limin Mao, Andrew Carr, Lucette A. Cysique
Format: Artikel
Sprache:eng
Schlagworte:
Aging
HIV
Neurocognition
Psychosocial factors
Trajectories
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Zusammenfassung:Background: High antiretroviral therapy (ART) coverage and viral suppression among people with HIV (PWH) in Australia provide a unique context to study individual cognitive trajectories, cognitive aging and factors associated with longitudinal cognitive function during chronic and stable HIV disease. Methods: Participants from the Predictors of Adherence to Antiretroviral Therapy study (n = 457, recruited between September 2013 and November 2015, median age = 52 years, and all with HIV RNA 0.5). Meaningful cognitive change was statistically defined (decline or improvement versus stability, i.e., 90% CI, that is p 
ISSN:2589-5370
2589-5370