Serial Interferon-Gamma Release Assay (IGRA) Testing to Monitor Treatment Responses in Cases of Feline Mycobacteriosis
The interferon-gamma release assay (IGRA) is used to diagnose cases of feline mycobacteriosis, but the use of serial testing to monitor treatment responses has not been evaluated in this species. From a population of cats that underwent IGRA testing for diagnostic investigation, individuals were ide...
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Veröffentlicht in: | Pathogens (Basel) 2021-05, Vol.10 (6), p.657 |
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Zusammenfassung: | The interferon-gamma release assay (IGRA) is used to diagnose cases of feline mycobacteriosis, but the use of serial testing to monitor treatment responses has not been evaluated in this species. From a population of cats that underwent IGRA testing for diagnostic investigation, individuals were identified with a pre- and end-of-treatment IGRA that passed control thresholds. The number of cats which reverted to negative at the end-of-treatment IGRA, changes in paired antigen-specific optical density (OD) values and differences in the pre-treatment antigen-specific OD values for those which underwent reversion were compared. Factors to explain reversion or recurrence of disease post-treatment were explored. Four of 18 cats (22%) reverted to negativity at the point of clinical resolution (
= 0.33), there was no difference in paired antigen-specific OD values (
≥ 0.12), and cats that reverted did not have a lower baseline OD value (
= 0.63). No statistically significant factors were identified to predict reversion (
≥ 0.08). Remaining positive at the end of treatment IGRA was not associated with recurrence of disease post-treatment (
= 0.34). Overall, these data suggest there is limited value in the use of the IGRA to monitor treatment responses in cats. |
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ISSN: | 2076-0817 2076-0817 |
DOI: | 10.3390/pathogens10060657 |