In-vitro and in-silico analyses of the thrombolytic potential of green kiwifruit

In-vitro and in-silico analyses of the thrombolytic potential of green kiwifruit

Cardiovascular diseases (CVDs), mainly caused by thrombosis complications, are the leading cause of mortality worldwide, making the development of alternative treatments highly desirable. In this study, the thrombolytic potential of green kiwifruit ( Actinidia deliciosa cultivar Hayward) was assesse...

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Veröffentlicht in:Scientific reports 2024-06, Vol.14 (1), p.13799-13
Hauptverfasser: Pinontoan, Reinhard, Purnomo, Jonathan Suciono, Avissa, Elvina Bella, Tanojo, Jessica Pricilla, Djuan, Moses, Vidian, Valerie, Samantha, Ariela, Jo, Juandy, Steven, Eden
Format: Artikel
Sprache:eng
Schlagworte:
631/114/2411
631/45/468
Actinidia
Actinidia - chemistry
Actinidin
Affinity
Animals
Blood coagulation
Cardiovascular diseases
Computer Simulation
Cultivars
Cysteine Endopeptidases - chemistry
Cysteine Endopeptidases - metabolism
Enzymes
Fibrin
Fibrin - chemistry
Fibrin - metabolism
Fibrinolytic activity
Fibrinolytic Agents - chemistry
Fibrinolytic Agents - pharmacology
Fruit - chemistry
Green kiwifruit
Humanities and Social Sciences
Humans
Hydrogen bonding
Molecular docking
Molecular Docking Simulation
Molecular dynamics
Molecular Dynamics Simulation
multidisciplinary
Plant Extracts - chemistry
Plant Extracts - pharmacology
Science
Science (multidisciplinary)
Thromboembolism
Thrombolysis
Thrombosis
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Beschreibung
Zusammenfassung:Cardiovascular diseases (CVDs), mainly caused by thrombosis complications, are the leading cause of mortality worldwide, making the development of alternative treatments highly desirable. In this study, the thrombolytic potential of green kiwifruit ( Actinidia deliciosa cultivar Hayward) was assessed using in-vitro and in-silico approaches. The crude green kiwifruit extract demonstrated the ability to reduce blood clots significantly by 73.0 ± 1.12% ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-64160-y