Ratio of carbon dioxide veno-arterial difference to oxygen arterial-venous difference is not associated with lactate decrease after fluid bolus in critically ill patients with hyperlactatemia: results from a prospective observational study

High ratio of the carbon dioxide veno-arterial difference to the oxygen arterial-venous difference (P CO /C O ) is associated with fluid bolus (FB) induced increase in oxygen consumption (VO ). This study investigated whether P CO /C O was associated with decreases in blood-lactate levels FB in critically ill patients with hyperlactatemia. This prospective observational study examined adult patients in the intensive care unit (ICU) with lactate levels > 1.5 mmol/L who received FBs. Blood-lactate levels were measured before and after FB under unchanged metabolic, respiratory, and hemodynamic conditions. The primary outcome was blood-lactate levels after FB. Significant decreases in blood-lactate levels were considered as blood-lactate levels