Complications of Diabetes 2016

According to the International Diabetes Federation in 2015, an estimated 415 million people globally were suffering from this condition [1]. In their study entitled “Influence of Age at Diagnosis and Time-Dependent Risk Factors on the Development of Diabetic Retinopathy in Patients with Type 1 Diabetes,” they maintain that age at onset of type 1 DM, indexes of glycemic control, HDL-cholesterol levels, and diastolic blood pressure are all parameters predicting DR. In this regard, the study “Heart Rate Variability as Early Biomarker for the Evaluation of Diabetes Mellitus Progress” by R. E. Arroyo-Carmona et al. has used heart rate variability (HRV) as a tool to identify early diabetic complications and progress of DM in streptozotocin-induced diabetic mice. (c) Macrovascular Complications. [...]in a review article entitled “The Role of AGE/RAGE Signaling in Diabetes-Mediated Vascular Calcification,” A. M. Kay et al. emphasize the key role of AGE/RAGE signaling on the promotion of DM-mediated vascular calcification. [...]in the review paper “Molecular and Electrophysiological Mechanisms Underlying Cardiac Arrhythmogenesis in Diabetes Mellitus,” G. Tse et al. discuss in detail the role of several cardiac factors (e.g., abnormalities in conduction or repolarization, electrophysiological, and structural remodeling) on arrhythmogenesis in patients with DM.