Anthocyanins from dietary black soybean potentiate glucose uptake in L6 rat skeletal muscle cells via up-regulating phosphorylated Akt and GLUT4

[Display omitted] •BSSCE and Cy3G significantly augmented the glucose uptake in L6 myotubes.•BSSCE and Cy3G modulated glucose uptake via Akt/GLUT4 signal pathway in L6 myotubes.•BSSCE displays potential as a diet approach for diabetes therapy. In order to illustrate the hypoglycemic mechanism of the dietary anthocyanins from black soybean, the effects of black soybean seed coat extract (BSSCE) and cyanidin-3-O-glucoside (Cy3G), the major anthocyanins of BSSCE on regulation of Akt and GLUT4 in L6 rat skeletal muscle cells were studied. BSSCE and Cy3G significantly augmented the glucose uptake in L6 myotubes in comparison to the normal control (p