Short Cationic Peptidomimetic Antimicrobials

Short Cationic Peptidomimetic Antimicrobials

The rapid growth of antimicrobial resistance against several frontline antibiotics has encouraged scientists worldwide to develop new alternatives with unique mechanisms of action. Antimicrobial peptides (AMPs) have attracted considerable interest due to their rapid killing and broad-spectrum activi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Antibiotics (Basel) 2019-04, Vol.8 (2), p.44
Hauptverfasser: Kuppusamy, Rajesh, Willcox, Mark, Black, David StC, Kumar, Naresh
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
antibacterials
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Antimicrobial peptides
Antimicrobial resistance
Apoptosis
Bacteria
Biocompatibility
cationic groups
Cations
Gram-positive bacteria
Lipids
Membranes
Peptides
Peptidomimetics
Proteolysis
Review
Toxicity
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The rapid growth of antimicrobial resistance against several frontline antibiotics has encouraged scientists worldwide to develop new alternatives with unique mechanisms of action. Antimicrobial peptides (AMPs) have attracted considerable interest due to their rapid killing and broad-spectrum activity. Peptidomimetics overcome some of the obstacles of AMPs such as high cost of synthesis, short half-life in vivo due to their susceptibility to proteolytic degradation, and issues with toxicity. This review will examine the development of short cationic peptidomimetics as antimicrobials.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics8020044