The Role of Inositols in Endocrine and Neuroendocrine Tumors

Inositols have demonstrated a role in cancer prevention and treatment in many kinds of neoplasms. Their molecular mechanisms vary from the regulation of survival and proliferative pathways to the modulation of immunity and oxidative stress. The dysregulation of many pathways and mechanisms regulated...

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Veröffentlicht in:	Biomolecules (Basel, Switzerland) Switzerland), 2024-08, Vol.14 (8), p.1004
Hauptverfasser:	Mormando, Marilda, Puliani, Giulia, Bianchini, Marta, Lauretta, Rosa, Appetecchia, Marialuisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant treatment Animals Antioxidants Cancer Cell cycle Cell differentiation Cell growth Cells Cellular signal transduction Cereals Colon Development and progression endocrine cancer Endocrine Gland Neoplasms - drug therapy Endocrine Gland Neoplasms - metabolism Epidermal growth factor Humans Hypothyroidism Inositol Inositol - metabolism Inositol - therapeutic use inositol hexakisphosphate inositols Insulin resistance Kinases Medical research Metabolism Metastasis Molecular modelling myo-inositols neuroendocrine neoplasms Neuroendocrine system Neuroendocrine tumors Neuroendocrine Tumors - drug therapy Neuroendocrine Tumors - metabolism Neuromodulation Oxidative Stress Prevention Prostate Proteins Review Selenium Signal transduction Thyroid cancer Type 2 diabetes Ultrasonic imaging
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Beschreibung
Zusammenfassung:	Inositols have demonstrated a role in cancer prevention and treatment in many kinds of neoplasms. Their molecular mechanisms vary from the regulation of survival and proliferative pathways to the modulation of immunity and oxidative stress. The dysregulation of many pathways and mechanisms regulated by inositols has been demonstrated in endocrine and neuroendocrine tumors but the role of inositol supplementation in this context has not been clarified. The aim of this review is to summarize the molecular basis of the possible role of inositols in endocrine and neuroendocrine tumors, proposing it as an adjuvant therapy.
ISSN:	2218-273X 2218-273X
DOI:	10.3390/biom14081004