Potential synergy between PSMA uptake and tumour blood flow for prediction of human prostate cancer aggressiveness

Background Both prostate-specific membrane antigen (PSMA) uptake and tumour blood flow (TBF) correlate with International Society of Urological Pathology (ISUP) Grade Group (GG) and hence prostate cancer (PCa) aggressiveness. The aim of the present study was to evaluate the potential synergistic benefit of combining the two physiologic parameters for separating significant PCa from insignificant findings. Methods From previous studies of [ 82 Rb]Rb positron emission tomography (PET) TBF in PCa, the 43 patients that underwent clinical [ 68 Ga]Ga-PSMA-11 PET were selected for this retrospective study. Tumours were delineated on [ 68 Ga]Ga-PSMA-11 PET or magnetic resonance imaging. ISUP GG was recorded from 52 lesions. Results [ 68 Ga]Ga-PSMA-11 maximum standardized uptake value (SUVmax) and [ 82 Rb]Rb SUVmax correlated moderately with ISUP GG (rho = 0.59 and rho = 0.56, both p