РRINCIPLES OF ANTIBACTERIAL THERAPY OF STREPTOCOCCAL TONSILLOPHARYNGITIS

Acute tonsillopharyngitis is one of the most common community-acquired infections. Up to 20–30 % cases of this disease in childhood are caused by the group A -hemolytic streptococcus and required systemic antibacterial treatment in order to arrest symptoms and localization of the infectious focus as well as to prevent purulent complications (acute rheumatic fever etc.). Despite the well-known total perceptibility of the group A -hemolytic streptococcus to penicillin in vitro, the cases of recurrent clinical course due to the lack of eradication of the causative agent during the initial penicillin therapy or re-infection are common. The analysis of both causes of clinical and/or bacteriological inefficacy of the treatment and the ways to overcome these problems, including with the help of alternative antibacterial drugs, are discussed in the article.