The influence of CASP8 D302H gene variant in colorectal cancer risk and prognosis

The influence of CASP8 D302H gene variant in colorectal cancer risk and prognosis

Apoptosis is defined as programmed cell death, which regulates cellular functions and various physiological responses. Several studies reported that Caspase genes play important roles in the apoptosis and inflammation process. Caspase-8 (CASP8) is a member of the cysteine protease family and a key r...

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Veröffentlicht in:Türk biyokimya dergisi 2023-07, Vol.48 (3), p.234-238
Hauptverfasser: Cacina, Canan, Turan Sürmen, Saime, Arıkan, Soykan, Pençe, Sadrettin, Yaylım, İlhan
Format: Artikel
Sprache:eng
Schlagworte:
apoptosis
caspase-8
colorectal cancer
gene variation
prognosis
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Zusammenfassung:Apoptosis is defined as programmed cell death, which regulates cellular functions and various physiological responses. Several studies reported that Caspase genes play important roles in the apoptosis and inflammation process. Caspase-8 (CASP8) is a member of the cysteine protease family and a key regulator gene in the induction of apoptosis. In present study, we aimed to investigate the possible associations between the CASP8; D302H (G>C) gene polymorphism and colorectal cancer risk and prognosis.
ISSN:1303-829X
1303-829X
DOI:10.1515/tjb-2022-0042