Epidemiology, radiology, and genetics of nicotine dependence in COPD

Cigarette smoking is the principal environmental risk factor for developing COPD, and nicotine dependence strongly influences smoking behavior. This study was performed to elucidate the relationship between nicotine dependence, genetic susceptibility to nicotine dependence, and volumetric CT finding...

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Veröffentlicht in:	Respiratory research 2011-01, Vol.12 (1), p.9-9, Article 9
Hauptverfasser:	Kim, Deog Kyeom, Hersh, Craig P, Washko, George R, Hokanson, John E, Lynch, David A, Newell, John D, Murphy, James R, Crapo, James D, Silverman, Edwin K
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis of Variance Case-Control Studies Chi-Square Distribution Cigarettes Colleges & universities Demographic aspects Diagnosis Disease susceptibility Environmental risk Epidemiology Female Forced Expiratory Volume Genetic aspects Genetic Predisposition to Disease Genetic susceptibility Genetic variance Genetics Genotypes Health aspects Hospitals Humans Linear Models Lung diseases, Obstructive Lungs Male Medical imaging Medicine Middle Aged Nerve Tissue Proteins - genetics Nicotine Observational studies Phenotype Polymorphism, Single Nucleotide Prospective Studies Public health Pulmonary Disease, Chronic Obstructive - diagnostic imaging Pulmonary Disease, Chronic Obstructive - epidemiology Pulmonary Disease, Chronic Obstructive - genetics Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Emphysema - diagnostic imaging Pulmonary Emphysema - epidemiology Pulmonary Emphysema - genetics Radiology Receptors, Nicotinic - genetics Risk Assessment Risk Factors Severity of Illness Index Single nucleotide polymorphisms Smokers Smoking Smoking - adverse effects Smoking - epidemiology Smoking - genetics Spirometry Tobacco Use Disorder - epidemiology Tobacco Use Disorder - genetics Tomography, X-Ray Computed United States - epidemiology Womens health
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Zusammenfassung:	Cigarette smoking is the principal environmental risk factor for developing COPD, and nicotine dependence strongly influences smoking behavior. This study was performed to elucidate the relationship between nicotine dependence, genetic susceptibility to nicotine dependence, and volumetric CT findings in smokers. Current smokers with COPD (GOLD stage ≥ 2) or normal spirometry were analyzed from the COPDGene Study, a prospective observational study. Nicotine dependence was determined by the Fagerstrom test for nicotine dependence (FTND). Volumetric CT acquisitions measuring the percent of emphysema on inspiratory CT (% of lung
ISSN:	1465-993X 1465-9921 1465-993X 1465-9921
DOI:	10.1186/1465-9921-12-9