Insulin sensitivity is associated with the observed variation of de novo lipid synthesis and body composition in finishing pigs

Variations in body composition among pigs can be associated with insulin sensitivity given the insulin anabolic effect. The study objectives were to characterize this association and to compare de novo lipogenesis and the gene expression in the adipose tissue of pigs of the same genetic background. Thirty 30–95 kg of body weight (BW) pigs, catheterized in the jugular vein participated into an oral glucose tolerance test (OGTT; 1.75 g glucose/kg of BW) to calculate insulin-related indexes. The 8 fattest and the 8 leanest pigs were used to determine the relative mRNA abundance of studied genes. The rate of lipogenesis was assessed by incorporation of [U- 13 C]glucose into lipids. The QUICKI and Matsuda indexes negatively correlated with total body lipids (r = − 0.67 and r = − 0.59; P