Association of the expression of Th1/Th2 cytokines and lymphocyte subsets with clinical characteristics and outcomes in 207 Chinese children with Burkitt's lymphoma

The systemic chemotherapy and intrathecal therapy (IT) were carried out according to Beijing Children’s Hospital B cell NHL protocol.This study was approved by the Ethical Committee of the Beijing Children’s Hospital (BCH) (No. Significant differences were observed in staging, risk group, BM invasio...

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Veröffentlicht in:	Chinese medical journal 2024-08, Vol.137 (16), p.2011-2013
Hauptverfasser:	Huang, Shuang, Jin, Ling, Yang, Jing, Peng, Yaguang, Gong, Wenyu, Hou, Shuo, Xing, Tianyu, Li, Zhigang, Duan, Yanlong
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Adolescent Blood Burkitt Lymphoma - immunology Cancer therapies Chemotherapy Child Child, Preschool Correspondence Cytokines Cytokines - metabolism East Asian People Female Humans Infant Lymphocyte Subsets - immunology Lymphocyte Subsets - metabolism Lymphocytes Lymphoma Male Medical prognosis Oncology Patients Pediatrics Remission (Medicine) Risk factors Th1 Cells - immunology Th2 Cells - immunology Tumor necrosis factor-TNF Tumors
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Zusammenfassung:	The systemic chemotherapy and intrathecal therapy (IT) were carried out according to Beijing Children’s Hospital B cell NHL protocol.This study was approved by the Ethical Committee of the Beijing Children’s Hospital (BCH) (No. Significant differences were observed in staging, risk group, BM invasion, and 3-year event-free survival (EFS) between the CNS-positive and CNS-negative groups. Additionally, our study revealed a relationship between lymphocyte expression and prognosis: univariable analysis showed that THL ≤39.3%, TNF ≤0.537%, Th17 5% were poor risk factors in the CNS-positive group (P
ISSN:	0366-6999 2542-5641 2542-5641
DOI:	10.1097/CM9.0000000000003059