A allele of ICAM-1 rs5498 and VCAM-1 rs3181092 is correlated with increased risk for periodontal disease

Periodontal disease (PD) is viewed today as multifactorial problems initiated and sustained by bacteria but significantly modified by the body's response to bacterial plaque. Recent studies have suggested that gene polymorphisms could be involved in the pathophysiology of periodontitis. This study aimed to investigate a possible correlation of the polymorphisms of intercellular adhesion molecule-1 ( ) and vascular cell adhesion molecule-1 ( ) with PD. The genotypes of and were initially determined in PD patients using denaturing high performance liquid chromatography (DHPLC). ELISA was then conducted to measure and protein levels. Next, the association of genotype distribution and expression with clinical indicators and severity of PD was analyzed. PD patients contained increased levels of hemoglobin A1c (HbA1c), total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL), increased and protein levels, and decreased high-density lipoprotein (HDL) level. The GG genotype and G allele at rs5498, as well as the AG and GG genotypes and G allele at rs3181092 may reduce PD risk. To sum up, the overexpressed and as well as A allele of rs5498 and rs3181092 is associated with the onset of PD.