Assessment of cerebral circulation through an intact skull using imaging photoplethysmography

The feasibility of assessing the parameters of cerebral hemodynamics without skull trepanation using imaging photoplethysmography with illumination in the near-infrared spectrum range was demonstrated for the first time. The results were obtained when studying changes in blood flow in the rat brain in response to short-term respiratory failure (apnea test). Translation of the results into clinical practice will be useful for the development of a method for non-invasive assessment of cerebral blood flow in patients with cerebrovascular diseases.