Application of donor predicted heart mass in heart transplant recipients with left ventricular assist device

An association between predicted heart mass (PHM) and post heart transplantation outcomes has been well established; however, there is limited data on the effect of donor PHM on recipients bridged with a durable left ventricular assist device (LVAD). This retrospective observational study seeks to c...

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Veröffentlicht in:JHLT open 2024-11, Vol.6, p.100150, Article 100150
Hauptverfasser: Reul, Ross M., Chen, Qiudong, Chan, Joshua L.
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Sprache:eng
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Zusammenfassung:An association between predicted heart mass (PHM) and post heart transplantation outcomes has been well established; however, there is limited data on the effect of donor PHM on recipients bridged with a durable left ventricular assist device (LVAD). This retrospective observational study seeks to challenge the theoretical benefit of oversizing donor hearts for recipients bridged with LVADs. Analysis of the United Network for Organ Sharing database revealed 10,806 adult patients with 1 of 3 durable LVADs (HeartMate 2, HeartMate 3 [HM3], HeartWare Ventricular Assist Device) between January 1, 2015 and December 31, 2021. Baseline characteristics were compared between 7 equally sized groups based on donor-to-recipient PHM. Univariable and multivariable Cox regression analyses were constructed to evaluate the effect of PHM size-matching on the primary outcome of 1-year post-transplant survival. Further analyses were performed specifically on HM3 patients and with PHM as a continuous variable. Multivariable analysis revealed that severely undersized donor hearts (PHM ratio
ISSN:2950-1334
2950-1334
DOI:10.1016/j.jhlto.2024.100150