INFLUENCE OF INTERLEUKIN-6 (-174 G/C) SINGLE NUCLEOTIDE POLYMORPHISM ON SERUM IL-6 LEVELS IN PREMATURE CORONARY ARTERY DISEASE

Objectives: Premature Coronary Artery Disease (PCAD) has taken the form of an epidemic in Pakistan and its incidence in young individuals is on the rise. The objective was to evaluate role of Interleukin-6 (-174 G/C) gene promoter polymorphism and the serum level of (IL-6) in the identification of PCAD. Methodology: The case-control study carried out at Army Medical College, Rawalpindi, Pakistan, from July, 2014 to Jan, 2015 in collaboration with University College London, UK. 150 patients 70% stenosis, in at least one coronary vessel on angiography, were labeled as cases. While 150 subjects who were angio-negative for disease were taken as controls. Genotyping was performed using Taqman Assay while serum IL-6 was measured using Enzyme Linked Immuno-sorbent Assay (ELISA). Results: Total 300 subjects participated in the study. Mean ± SD age of PCAD patients was 40 ± 3.80 while in controls it was 38 ± 7.8 yrs. Serum IL-6 levels were significantly high in PCAD patients (p