Living Engineered Bacterial Therapeutics: Emerging Affordable Precision Interventions

ABSTRACT Live biotherapeutic products (LBPs), including engineered bacteria, are rapidly emerging as potential therapeutic interventions. These innovative therapies can serve as live in situ drug delivery platforms for the direct deposition of therapeutic payloads, including complex biologics, at sites of disease. This approach offers a platform likely to enhance therapeutic efficacy and decrease off‐target side effects. LBPs also can likely be distributed at a relatively low price point, as their production can be economically scaled up. LBPs represent an exciting new means for ensuring healthy lives and promoting well‐being for all ages, aligning with the World Health Organization's sustainable development goal 3. Smart microbes are rapidly emerging as potential therapeutic interventions. This review is focused on discussing the potential of engineered bacteria for ensuring healthy lives and promoting well‐being for all ages, aligning with the World Health Organization's sustainable development goal 3.