Prognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysis

The mammalian homologs of Lin-28, Lin28 (also called Lin28A) and Lin28B, are promising cancer biomarkers. This meta-analysis was performed to evaluate the prognostic values of Lin28A and Lin28B in multiple human malignancies. Systematic searches of the PubMed, Web of Science and Embase were used to...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer Cell International 2019-04, Vol.19 (1), p.79-79, Article 79
Hauptverfasser:	Zhang, Jiayi, Xu, Aiming, Miao, Chenkui, Yang, Jie, Gu, Min, Song, Ninghong
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioindicators Biological markers Biomarker Biomarkers Breast cancer Cancer Carcinogenesis Colorectal cancer Development and progression Gastric cancer Genetic aspects Homology Human tumors Lin-28 Liver cancer Medical prognosis Meta-analysis Methods MicroRNA MicroRNAs Ovarian cancer Physiological aspects Primary Research Prognosis Stem cells Studies Survival Survival analysis Systematic review Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The mammalian homologs of Lin-28, Lin28 (also called Lin28A) and Lin28B, are promising cancer biomarkers. This meta-analysis was performed to evaluate the prognostic values of Lin28A and Lin28B in multiple human malignancies. Systematic searches of the PubMed, Web of Science and Embase were used to identify relevant studies. Pooled hazard ratios (HRs) with 95% confidence intervals (CI) for overall survival (OS), recurrence-free survival (RFS), disease-free survival (DFS), or progression-free survival (PFS) were respectively calculated. 3772 Lin28A-associated patients and 1730 Lin28B-related cases were ultimately enrolled in this meta-analysis. The elevated expression level of Lin28A was significantly associated with poor OS (HR = 1.60, P
ISSN:	1475-2867 1475-2867
DOI:	10.1186/s12935-019-0788-z