Diffuse white matter abnormality in very preterm infants at term reflects reduced brain network efficiency

Diffuse white matter abnormality in very preterm infants at term reflects reduced brain network efficiency

•Most preterm infants exhibit regions of high signal intensity on T2 MRI at term.•Debate remains as to whether this signal (DWMA) is pathological.•We quantified DWMA and used graph theory to measure brain network efficiency.•Whole-brain and regional network efficiency at term decreased with greater...

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Veröffentlicht in:NeuroImage clinical 2021-01, Vol.31, p.102739-102739, Article 102739
Hauptverfasser: Kline, Julia E., Illapani, Venkata Sita Priyanka, Li, Hailong, He, Lili, Yuan, Weihong, Parikh, Nehal A.
Format: Artikel
Sprache:eng
Schlagworte:
Diffuse white matter abnormality
diffusion MRI
Graph theory
Regular
Very preterm
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Zusammenfassung:•Most preterm infants exhibit regions of high signal intensity on T2 MRI at term.•Debate remains as to whether this signal (DWMA) is pathological.•We quantified DWMA and used graph theory to measure brain network efficiency.•Whole-brain and regional network efficiency at term decreased with greater DWMA.•DWMA in very preterm infants is associated with reduced brain efficiency at term. Between 50 and 80% of very preterm infants (
ISSN:2213-1582
2213-1582
DOI:10.1016/j.nicl.2021.102739