Destroy, what destroys you

New evidence indicates the importance of CD137 for controlling Epstein-Barr virus (EBV) infections. (1) Mutations in CD137 predispose to EBV-associated diseases. (2) EBV induces ectopic CD137 expression, thereby activating a negative feed-back regulation and reducing T cell costimulation. These find...

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Veröffentlicht in:	Oncoimmunology 2020-01, Vol.9 (1), p.1685301-1685301, Article 1685301
Hauptverfasser:	Luu, Khang, Nickles, Emily, Schwarz, Herbert
Format:	Artikel
Sprache:	eng
Schlagworte:	CD137 Epstein-Barr virus Hodgkin lymphoma Immunology Life Sciences & Biomedicine mutations Oncology Point-of-View Science & Technology
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	New evidence indicates the importance of CD137 for controlling Epstein-Barr virus (EBV) infections. (1) Mutations in CD137 predispose to EBV-associated diseases. (2) EBV induces ectopic CD137 expression, thereby activating a negative feed-back regulation and reducing T cell costimulation. These findings suggest CD137 agonists as new treatments for EBV-associated diseases.
ISSN:	2162-402X 2162-4011 2162-402X
DOI:	10.1080/2162402X.2019.1685301