Metabolic Disorders in Patients with Chronic Hepatitis B Virus Infection: Coffee as a Panacea? (ANRS CO22 Hepather Cohort)

People living with chronic hepatitis B virus (HBV) infection are at high risk of liver disease progression, which is positively associated with metabolic disorders, but inversely associated with dyslipidemia. Diet, including dietary antioxidants, is a lever of metabolic disorder management. In parti...

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Veröffentlicht in:Antioxidants 2022-02, Vol.11 (2), p.379
Hauptverfasser: Barré, Tangui, Fontaine, Hélène, Pol, Stanislas, Ramier, Clémence, Di Beo, Vincent, Protopopescu, Camelia, Marcellin, Fabienne, Bureau, Morgane, Bourlière, Marc, Dorival, Céline, Petrov-Sanchez, Ventzislava, Asselah, Tarik, Delarocque-Astagneau, Elisabeth, Larrey, Dominique, Duclos-Vallée, Jean-Charles, Carrat, Fabrice, Carrieri, Patrizia, On Behalf Of The Anrs/Afef Hepather Study Group
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Sprache:eng
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Zusammenfassung:People living with chronic hepatitis B virus (HBV) infection are at high risk of liver disease progression, which is positively associated with metabolic disorders, but inversely associated with dyslipidemia. Diet, including dietary antioxidants, is a lever of metabolic disorder management. In particular, elevated coffee consumption is associated with different metabolic outcomes in the general population. We aimed to test whether such associations occur in HBV-infected people. Based on cross-sectional data from the ANRS CO22 Hepather cohort, we performed logistic regression models with (i) dyslipidemia, (ii) hypertension, and (iii) diabetes as outcomes, and with demographic, clinical, and socio-behavioral (including coffee consumption) data as explanatory variables. Among 4746 HBV-infected patients, drinking ≥3 cups of coffee per day was associated with a higher risk of dyslipidemia (adjusted odds ratio [95% confidence interval] 1.49 [1.10-2.00], = 0.009) and a lower risk of hypertension (0.64 [0.50-0.82], = 0.001). It was not associated with diabetes. Elevated coffee consumption was associated with a higher risk of dyslipidemia and a lower risk of hypertension in HBV-infected patients, two effects expected to be associated with favorable clinical outcomes. Further studies should test whether such metabolic benefits translate into reduced mortality risk in this population.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox11020379