Generation of 3 human induced pluripotent stem cell lines LUMCi005-A, B and C from a Hereditary Cerebral Hemorrhage with Amyloidosis-Dutch type patient

Generation of 3 human induced pluripotent stem cell lines LUMCi005-A, B and C from a Hereditary Cerebral Hemorrhage with Amyloidosis-Dutch type patient

Hereditary Cerebral Hemorrhage with Amyloidosis-Dutch type (HCHWA-D) is an autosomal dominant hereditary disease caused by a point mutation in exon 17 of the APP gene. We generated human induced pluripotent stem cells (hiPSCs) from a symptomatic HCHWA-D patient by using non-integrating Sendai virus...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Stem cell research 2019-01, Vol.34, p.101359-101359, Article 101359
Hauptverfasser: Daoutsali, Elena, Buijsen, Ronald A.M., van de Pas, Simone, Jong, Anke 't, Mikkers, Harald, Brands, Tom, Eussen, Bert, de Klein, Annelies, van der Graaf, Linda M., Pepers, Barry A., Freund, Christian, Terwindt, Gisela M., Orlova, Valeria V., van Roon-Mom, Willeke M.C.
Format: Artikel
Sprache:eng ; fre
Schlagworte:
Base Sequence
Cell Culture Techniques - methods
Cell Line
Cerebral Amyloid Angiopathy, Familial - pathology
Female
Humans
Induced Pluripotent Stem Cells - pathology
Middle Aged
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Hereditary Cerebral Hemorrhage with Amyloidosis-Dutch type (HCHWA-D) is an autosomal dominant hereditary disease caused by a point mutation in exon 17 of the APP gene. We generated human induced pluripotent stem cells (hiPSCs) from a symptomatic HCHWA-D patient by using non-integrating Sendai virus (SeV). The newly generated hiPSCs express all pluripotency markers, have a normal karyotype, carry the Dutch mutation, can differentiate in the three germ layers in vitro and are SeV free.
ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2018.101359