Retrotransposons Down- and Up-Regulation in Aging Somatic Tissues

The transposon theory of aging hypothesizes the activation of transposable elements (TEs) in somatic tissues with age, leading to a shortening of the lifespan. It is thought that TE activation in aging produces an increase in DNA double-strand breaks, contributing to genome instability and promoting...

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Veröffentlicht in:	Cells (Basel, Switzerland) Switzerland), 2021-12, Vol.11 (1), p.79
Hauptverfasser:	Giordani, Giorgia, Cavaliere, Valeria, Gargiulo, Giuseppe, Lattanzi, Giovanna, Andrenacci, Davide
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - genetics Animals Communication DNA damage Down-Regulation - genetics Drosophila melanogaster - genetics Experiments Females Gene expression Genomes Genomic instability Genotype & phenotype gypsy Hypotheses Idefix Inflammation Insects Life span longevity Middle age Mutation Ovaries Retroelements - genetics Standard deviation transposons Up-Regulation - genetics ZAM
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Beschreibung
Zusammenfassung:	The transposon theory of aging hypothesizes the activation of transposable elements (TEs) in somatic tissues with age, leading to a shortening of the lifespan. It is thought that TE activation in aging produces an increase in DNA double-strand breaks, contributing to genome instability and promoting the activation of inflammatory responses. To investigate how TE regulation changes in somatic tissues during aging, we analyzed the expression of some TEs, as well as a source of small RNAs that specifically silence the analyzed TEs; the cluster named . We found significant variations in the expression levels of all the analyzed TEs during aging, with a trend toward reduction in middle-aged adults and reactivation in older individuals that suggests dynamic regulation during the lifespan.
ISSN:	2073-4409 2073-4409
DOI:	10.3390/cells11010079