Clinical Significance of Composition and Functional Diversity of the Vaginal Microbiome in Recurrent Vaginitis

The vaginal microbiome protects the female genital tract from various diseases, such as vaginitis, a vaginal inflammation characterized by abnormal discharge, itching, and pain. To evaluate the clinical relationship between the vaginal microbiome and the pathophysiology of recurrent vaginitis (RV),...

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Veröffentlicht in:Frontiers in microbiology 2022-02, Vol.13, p.851670-851670
Hauptverfasser: Kim, Min Jeong, Lee, Seungok, Kwon, Mi Yeon, Kim, Myungshin
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Sprache:eng
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Zusammenfassung:The vaginal microbiome protects the female genital tract from various diseases, such as vaginitis, a vaginal inflammation characterized by abnormal discharge, itching, and pain. To evaluate the clinical relationship between the vaginal microbiome and the pathophysiology of recurrent vaginitis (RV), we investigated the microbiome taxonomic profile (MTP) in the vaginal samples of Korean female patients with RV. Forty women of reproductive age diagnosed with RV were enrolled. The vaginal MTP of patients was analyzed using 16S ribosomal RNA gene sequencing, and the results were compared with that of healthy women (  = 100). Further, the association of the vaginal community state type (CST) with the clinical characteristics was analyzed. The species abundance of MTP was significantly lower in patients with RV than in healthy women (  
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2022.851670