Retinoblastoma genetics in India: From research to implementation

Retinoblastoma is the prototypic genetic cancer. India carries the biggest burden of retinoblastoma globally, with an estimated 1500 new cases annually. Recent advances in retinoblastoma genetics are reviewed, focusing specifically on information with clinical significance to patients. The Indian li...

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Veröffentlicht in:	Indian journal of ophthalmology 2015-03, Vol.63 (3), p.219-226
1. Verfasser:	Dimaras, Helen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal uveitis model Biomedical Research Brachytherapy Care and treatment chemotherapy Conjunctiva cornea cryopexy cytomegalovirus retinitis animal model endotoxin-induced uveitis experimental autoimmune uveitis Genetic aspects Genetic Predisposition to Disease genetics Humans India India - epidemiology intra ocular tumors Intraocular lymphoma Medical genetics melanoma Morbidity - trends ocular surface ocular surface squamous neoplasia photocoagulation retina Retinal Neoplasms - diagnosis Retinal Neoplasms - epidemiology Retinal Neoplasms - genetics Retinoblastoma Retinoblastoma - diagnosis Retinoblastoma - epidemiology Retinoblastoma - genetics Retinoblastoma Binding Proteins - genetics Review Risk factors spontaneous tubercular uveitis animal model tumor Ubiquitin-Protein Ligases - genetics vitreous
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Beschreibung
Zusammenfassung:	Retinoblastoma is the prototypic genetic cancer. India carries the biggest burden of retinoblastoma globally, with an estimated 1500 new cases annually. Recent advances in retinoblastoma genetics are reviewed, focusing specifically on information with clinical significance to patients. The Indian literature on retinoblastoma clinical genetics is also highlighted, with a comment on challenges and future directions. The review concludes with recommendations to help clinicians implement and translate retinoblastoma genetics to their practice.
ISSN:	0301-4738 1998-3689
DOI:	10.4103/0301-4738.156917