Drug-drug interactions with antiretroviral therapy among people living with HIV in Asia and other regions: risk factors and impact on indicators of health-related quality of life

Introduction While studies have extensively examined the clinical and pharmacokinetic correlates of drug-drug interactions (DDIs) with antiretroviral therapy (ART), less is known about DDIs from the perspective of people living with HIV (PLHIV). Among an international sample of PLHIV, we examined experiences, concerns and challenges regarding DDIs. Methods Data came from an international, web-based survey that was conducted among adult PLHIV aged ≥18 years who were receiving ART during 2019 (Positive Perspectives Wave 2, n=2389). Data were analyzed using descriptive statistics and with a special focus on the Asian region comprising participants from China, Taiwan, Japan, and South Korea (n=230). Multivariable analyses were performed using pooled data from all 2389 participants. Statistical significance was at p