Effects of achillea millifolium extract consumption by pregnant mice on pregnancy outcome and reproductive system of their female off spring

Background : Achillea millefolium (Yarrow) is medicinal plant that is traditionally used against inflammatory and spasmodic gastrointestinal compliant. Objective : To study the effect of the consumption of Achillea extract by pregnant mice on pregnancy out come and on the reproductive system of the female off spring. Materials and Methods : 70 adult pregnant female mice at age of 40-45 days were used in this study. These 70 mice were divided equally into two groups : experimental group (G1) and control group (G2). The experimental group was given 1mg / kg body weight / 1ml of D. W of Achillea millefolium extract orally during 3 weeks of pregnancy, while the control group was given 1ml of D.W orally alone and for the same period. After delivery the number and weight of the litters were recorded. 40 days after delivery, the weight of the female reproductive system was estimated, histological sections were done for the ovaries and oviducts, their diameters were measured, in addition serum was taken from these mice and measurement of FSH, LH and E2 was done for both groups. Results : The results of the experimental group showed highly significant decrease in litter size and significant decrease their weight. In addition young females born from treated mothers showed significant decrease in the weight of reproductive system, diameter of ovaries and diameter of oviducts. Also, significant decrease was noticed in the level of FSH, LH and Estradiol level in the experimental group. Conclusion : Consuming of Achillea millifolium extract during pregnancy will produce bad effect on the pregnancy out come in addition to bad effect on the reproductive system of the female offspring. خلفية الدراسة : القيصوم (ياري) هو نبات طبي استعمل تقليديا ضد الالتهابات و التقلصات المعوية. هدف الدراسة : لدراسة تأثير استهلاك مستخلص القيصوم من قبل الأمهات الحوامل على نتائج الحمل و الجهاز التكاثري لإناث المواليد. طريقة العمل : استعمل في هذه الدراسة سبعين فأرة حامل بعمر 40–45 يوما. قسمت هذه الفئران إلى مجموعتين متساويتين : مجموعة الاختبار و مجموعة السيطرة. أعطيت مجموعة الاختبار 1 ملغم / كغم من وزن الفأرة من مستخلص نبات القيصوم مذابا في 1 مل من الماء المقطر فمويا و لمدة 3 أسابيع خلال الحمل, بينما أعطيت مجموعة السيطرة 1 مل من الماء المقطر فقط فمويا و لنفس الفترة. بعد الولادة تم احتساب عدد و أوزان المواليد للمجموعتين. بعد أربعين يوما من الولادة تم قياس أوزان الجهاز التكاثري لإناث المواليد و أخذت مقاطع نسيجية للمبايض و القنوات الناقلة للبيض و تم احتساب أقطارها. إضافة إلى ذلك تم أخذ عينات دم منه