Response to "optic nerve sheath diameter guided detection of sepsis associated encephalopathy"

[...]regarding the blind method, being uninformed of the clinical diagnoses of patients is unavailing, since clues will still be found in patients’ clinical manifestations (soberness/delirium/irritability/sleepiness/coma). [...]two trained physicians in intensive ultrasound were selected for joint measurement. [...]the sepsis patients included in the research were aged between 18 and 93. [...]no significant difference was identified in serum albumin concentration among patients in different groups (sepsis group, sepsis-associated encephalopathy group, and sepsis-associated encephalopathy recovery group) (28.9 [25.5,31.05], 30.5 [27.6,32.2], 34.75 [29.7,36]), especially between the sepsis group and the sepsis-associated encephalopathy group. [...]a small correlation between albumin and ONSD cannot prove the role of albumin in dominating intracranial pressure/onsd.