Four 14(13 → 12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea
Four new rearranged 6/6/5/6-fused lanostane-type triterpenoids, kadcoccitanes A–D ( 1 – 4 ), were isolated from the roots of Kadsura coccinea , and their structures were mainly elucidated by comprehensive analysis of their spectroscopic data. Additionally, the structure of 1 was ambiguously verified...
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| Veröffentlicht in: | Natural Products and Bioprospecting 2019-06, Vol.9 (3), p.165-173 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Four new rearranged 6/6/5/6-fused lanostane-type triterpenoids, kadcoccitanes A–D (
1
–
4
), were isolated from the roots of
Kadsura coccinea
, and their structures were mainly elucidated by comprehensive analysis of their spectroscopic data. Additionally, the structure of
1
was ambiguously verified by single-crystal X-ray diffraction, while the structure of
2
, which features a novel 8,16-epoxy motif, was validated by quantum chemical calculation of NMR parameters and ECD spectrum. Moreover,
1
and
4
were found to exhibited anticoagulant activity, while
3
and
4
were found to possess anti-platelet aggregation activity. |
|---|---|
| ISSN: | 2192-2195 2192-2209 |
| DOI: | 10.1007/s13659-019-0203-4 |