Long‐term overall survival and toxicities of ABVD vs BEACOPP in advanced Hodgkin lymphoma: A pooled analysis of four randomized trials

Purpose We explored the potential overall survival (OS) benefit of bleomycin, etoposide, doxorubicin (Adriamycin), cyclophosphamide, vincristine (Oncovin), procarbazine, and prednisone (BEACOPP) over doxorubicin (Adriamycin), bleomycin, vinblastine, and dacarbazine (ABVD) in a pooled analysis of fou...

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Veröffentlicht in:Cancer medicine (Malden, MA) MA), 2020-09, Vol.9 (18), p.6565-6575
Hauptverfasser: André, Marc P. E., Carde, Patrice, Viviani, Simonetta, Bellei, Monica, Fortpied, Catherine, Hutchings, Martin, Gianni, Alessandro M., Brice, Pauline, Casasnovas, Olivier, Gobbi, Paolo G., Zinzani, Pier Luigi, Dupuis, Jehan, Iannitto, Emilio, Rambaldi, Alessandro, Brière, Josette, Clément‐Filliatre, Laurianne, Heczko, Marian, Valagussa, Pinuccia, Douxfils, Jonathan, Depaus, Julien, Federico, Massimo, Mounier, Nicolas
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Sprache:eng
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Zusammenfassung:Purpose We explored the potential overall survival (OS) benefit of bleomycin, etoposide, doxorubicin (Adriamycin), cyclophosphamide, vincristine (Oncovin), procarbazine, and prednisone (BEACOPP) over doxorubicin (Adriamycin), bleomycin, vinblastine, and dacarbazine (ABVD) in a pooled analysis of four randomized trials. Patients and methods Primary objective was to evaluate the OS impact of BEACOPP using individual patient data. Secondary objectives were progression‐free survival (PFS), secondary cancers, and use of autologous stem cell transplantation (ASCT). Results About 1227 patients were included. The 7‐year OS was 84.3% (95% CI 80.8‐87.2) for ABVD vs 87.7% (95% CI 84.5‐90.2) for BEACOPP. Two follow‐up periods were identified based on survival curves and hazard ratio (HR) over time. For the first 18 months, there was no difference. For the second period of ≥18 months, ABVD patients had a higher death risk (HRABVD vs BEACOPP = 1.59; 95% CI 1.09‐2.33). A Cox model stratified by trial and evaluating the effect of treatment and International Prognostic Index (IPI) score as fixed effects showed that both were statistically significant (treatment, P = .0185; IPI score, P = .0107). The 7‐year PFS was 71.1% (95% CI 67.1‐74.6) for ABVD vs 81.1% (95% CI 77.5‐84.2) for BEACOPP (P 
ISSN:2045-7634
2045-7634
DOI:10.1002/cam4.3298