Biology of Interleukin-17 and Its Pathophysiological Significance in Sepsis

The interleukin (IL)-17 family includes six structure-related cytokines (A-F). To date, majority of studies have focused on IL-17A. IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. Several recent studies have indicated that IL-17A is a bi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Frontiers in immunology 2020-07, Vol.11, p.1558-1558
Hauptverfasser:	Ge, Yun, Huang, Man, Yao, Yong-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers cytokine Cytokines - metabolism Disease Management Disease Susceptibility Humans immune response Immunology inflammatory response interleukin-17 Interleukin-17 - genetics Interleukin-17 - metabolism Receptors, Interleukin-17 - metabolism sepsis Sepsis - complications Sepsis - diagnosis Sepsis - etiology Sepsis - metabolism Signal Transduction T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The interleukin (IL)-17 family includes six structure-related cytokines (A-F). To date, majority of studies have focused on IL-17A. IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. Several recent studies have indicated that IL-17A is a biomarker as well as a therapeutic target in sepsis. In the current review, we summarize the biological functions of IL-17, including IL-17-mediated responses and signal transduction pathways, with particular emphasis on clinical relevance to sepsis.
ISSN:	1664-3224 1664-3224
DOI:	10.3389/fimmu.2020.01558