Insights gained from ancient biomolecules into past and present tuberculosis—a personal perspective

Highlights • The weak relationship between paleopathology and past tuberculosis (TB) infections is described. • Detection methods for Mycobacterium tuberculosis ancient biomolecules are critically reviewed. • The link between strains and lineages of M. tuberculosis and their human host is explained....

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Veröffentlicht in:	International journal of infectious diseases 2017-03, Vol.56 (C), p.176-180
1. Verfasser:	Donoghue, Helen D
Format:	Artikel
Sprache:	eng
Schlagworte:	Ancient DNA (aDNA) Bacterial cell wall lipids Coinfection - genetics Coinfection - immunology DNA, Bacterial - genetics Evolution Evolution, Molecular History, Ancient Human migration Humans Infectious Disease Morbidity Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Paleomicrobiology Paleopathology Pulmonary/Respiratory Tuberculosis - history Tuberculosis - immunology Tuberculosis - microbiology
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Beschreibung
Zusammenfassung:	Highlights • The weak relationship between paleopathology and past tuberculosis (TB) infections is described. • Detection methods for Mycobacterium tuberculosis ancient biomolecules are critically reviewed. • The link between strains and lineages of M. tuberculosis and their human host is explained. • Insights from ancient M. tuberculosis on our understanding of modern TB infections are made clear.
ISSN:	1201-9712 1878-3511
DOI:	10.1016/j.ijid.2016.11.413