NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors

NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors

“Tumor-educated platelets” have recently generated substantial interest for the diagnosis of cancer. We hypothesized that tumor educated platelets from patients with brain tumors will reflect altered metabolism compared to platelets from healthy volunteers. Here, in a pilot study, we have employed n...

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Veröffentlicht in:Reports (MDPI) 2021-10, Vol.4 (4), p.32
Hauptverfasser: Pudakalakatti, Shivanand, Audia, Alessandra, Mukhopadhyay, Anirudh, Enriquez, José S., Bourgeois, Dontrey, Tayob, Nabihah, Zacharias, Niki M., Millward, Steven W., Carson, Daniel, Farach-Carson, Mary C., Lang, Frederick F., Heimberger, Amy B., Bhat, Krishna P., Bhattacharya, Pratip K.
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine triphosphate
Biomarkers
Biopsy
Blood platelets
Brain cancer
brain tumor
Cancer therapies
Disease
Magnetic resonance imaging
Metabolism
Metabolites
metabolomics
Metastasis
Nervous system
NMR
NMR spectroscopy
Nuclear magnetic resonance
Patients
platelets
Radiation
Spectrum analysis
Surgery
Tumors
Volunteers
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Zusammenfassung:“Tumor-educated platelets” have recently generated substantial interest for the diagnosis of cancer. We hypothesized that tumor educated platelets from patients with brain tumors will reflect altered metabolism compared to platelets from healthy volunteers. Here, in a pilot study, we have employed nuclear magnetic resonance (NMR) spectroscopy in platelets from brain tumor patients to demonstrate altered metabolism compared to the platelets obtained from healthy volunteers.
ISSN:2571-841X
2571-841X
DOI:10.3390/reports4040032