Toward human intervention-free clinical diagnosis of intracranial aneurysm via deep neural network

Intracranial aneurysm (IA) is an enormous threat to human health, which often results in nontraumatic subarachnoid hemorrhage or dismal prognosis. Diagnosing IAs on commonly used computed tomographic angiography (CTA) examinations remains laborious and time consuming, leading to error-prone results in clinical practice, especially for small targets. In this study, we propose a fully automatic deep-learning model for IA segmentation that can be applied to CTA images. Our model, called Global Localization-based IA Network (GLIA-Net), can incorporate the global localization prior and generates the fine-grain three-dimensional segmentation. GLIA-Net is trained and evaluated on a big internal dataset (1,338 scans from six institutions) and two external datasets. Evaluations show that our model exhibits good tolerance to different settings and achieves superior performance to other models. A clinical experiment further demonstrates the clinical utility of our technique, which helps radiologists in the diagnosis of IAs. •GLIA-Net is a deep learning method for the clinical diagnosis of IAs•It can be applied directly to CTA images without any laborious preprocessing•A clinical study demonstrates its effectiveness in assisting diagnosis•An IA dataset of 1,338 CTA cases from six institutions is publicly released Intracranial aneurysms (IAs) are enormous threats to human health with a prevalence of approximately 4%. The rupture of IAs usually causes death or severe damage to the patients. To enhance the clinical diagnosis of IAs, we present a deep learning model (GLIA-Net) for IA detection and segmentation without laborious human intervention, which achieves superior diagnostic performance validated by quantitative evaluations as well as a sophisticated clinical study. We anticipate that the publicly released data and the artificial intelligence technique would help to transform the clinical diagnostics and precision treatments of cerebrovascular diseases. They may also revolutionize the landscape of healthcare and biomedical research in the future. Intracranial aneurysm (IA) diagnosis on CTA images is laborious and time consuming in clinical routine. By combining global risk prediction with local IA recognition, the proposed GLIA-Net can robustly and efficiently assist radiologists in clinical practice without any pre- or postprocessing. The state-of-the-art performance has been validated via a multi-cohort dataset, which has been publicly released to democratize dee